Easy Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is more than just comfort food—it’s a rich, savory experience that brings bold Cajun spice together with velvety garlic mozzarella indulgence. This dish isn’t your everyday pasta; it’s the one you make when you want something wildly flavorful and comforting in every single bite.

Welcome to CookTune—where recipes turn into family traditions. Our story began in a small Southern kitchen filled with music, laughter, and the aroma of soul-hugging dishes passed down through generations. Inspired by our family’s deep love for bold flavors and cozy meals, we created CookTune to celebrate recipes that speak to your taste buds and your heart. And nothing does that quite like today’s feature: Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce.

Whether you’re a home cook looking to wow dinner guests or a weekday warrior in search of a simple one-pot wonder, this recipe wraps spicy, cheesy, and creamy elements into one unforgettable forkful. In this article, we’ll break down everything you need to master this hearty classic—from ingredients and techniques to essential pro tips, FAQ answers, and bonus serving suggestions.

So let’s dive into this soul-satisfying, flavor-rich pasta plate you’ll want to make again and again.

Don’t miss our Lemon Shallot Chicken for another zesty poultry favorite.

Table of Contents

Table of Contents

What Makes Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce So Special

The Unique Blend of Creamy and Spicy

The marriage of heat and cheese is no secret to comfort food fans, but Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce takes it to the next level. You’ve got robust Cajun seasoning mingling with sweet, aromatic garlic and smooth melted mozzarella to create a sauce that’s both sharp and silky. The spicy punch from smoked paprika and red pepper flakes is mellowed out by the buttery cream cheese and milk-based roux, giving you that perfect balance.

Southern Roots Meet Italian Flair

This dish is a melting pot of culinary cultures. While the Cajun spices hail from Louisiana’s iconic Creole cooking, the use of spaghetti and mozzarella brings Italian comfort food into play. This fusion is what makes it so approachable—and unforgettable.

One-Skillet Simplicity, Restaurant-Level Results

Who doesn’t love a pasta dish that tastes like it came from a five-star kitchen but only uses one pot? You’ll brown chicken, create a flavorful roux, melt cheese into a dreamy sauce, and combine it all in a single skillet. Less cleanup. More flavor.

Customizable Heat Level

Want it fiery? Toss in extra red pepper flakes. Prefer it mild and creamy? Dial back the Cajun. This dish adapts to your taste without compromising on texture or richness.

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Ingredients and Their Roles in Flavor-Building

Cajun-Spiced Chicken: Flavorful Foundation

To start, we season 1 pound of boneless, skinless chicken breasts with 2 tablespoons of Cajun seasoning and 1 teaspoon of smoked paprika. This combo adds depth, earthiness, and a little kick to every bite. Cajun seasoning typically blends paprika, cayenne, garlic powder, oregano, and thyme—perfect for building a bold base flavor.

A splash of olive oil helps the seasoning stick and adds healthy fat for browning. Once seared, the chicken is juicy and crisp on the outside—a key contrast to the creamy spaghetti.

Pro Tip: Let the seasoned chicken rest for 10 minutes before cooking. This helps the spices permeate the meat more deeply.

Al Dente Spaghetti: The Perfect Pasta Texture

We use 1 pound of spaghetti cooked until just al dente. Why not softer? Because it finishes cooking in the sauce, soaking up all that garlicky, cheesy goodness without turning mushy.

Garlic-Butter Roux: The Sauce’s Rich Heart

Here’s where the magic begins. Melt 4 tablespoons of butter in the same skillet you cooked the chicken in, then stir in 4 cloves of minced garlic and 1/4 cup of flour. This roux thickens the sauce and layers in a nutty, garlicky base.

Check out this flavor-packed Creamy Garlic Seafood Pasta for another garlic-lover’s dream.

Dairy Dream Team: Milk, Broth, Cream Cheese & Cheeses

We use 3 cups of whole milk and 1 cup of chicken broth for the liquid base. The milk provides creaminess, while the broth infuses a savory depth that pairs beautifully with the seasoned chicken.

Once the roux is smooth, 8 ounces of softened cream cheese melt right in—giving the sauce an ultra-silky texture. Then comes the cheesy trio:

• 2 cups shredded mozzarella (mild, melty bliss)
• 1/2 cup grated Parmesan (nutty sharpness)
• And optionally, a sprinkle of red pepper flakes for those who crave a kick

Optional Twist: Add sun-dried tomatoes or sautéed mushrooms for extra layers of flavor.

Final Touch: Season to Taste

Finish the sauce with salt and freshly ground black pepper to balance it all out. Taste as you go—this step is key to dialing in the richness and spice.

Step-by-Step Method to Cook Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Prep the Chicken with Bold Cajun Seasoning

Start by slicing 1 pound of boneless, skinless chicken breasts into bite-sized pieces. In a bowl, toss the chicken with:

• 2 tablespoons olive oil
• 2 tablespoons Cajun seasoning
• 1 teaspoon smoked paprika

Mix thoroughly so every piece gets coated with that fiery, peppery blend. This is the soul of your Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce—make it bold!

Let it sit for 10 minutes to absorb flavor while you prep the rest.

Want even more flavor? Marinate it overnight for a deeper Cajun punch.

Boil the Pasta Al Dente

In a large pot of salted boiling water, cook 1 pound of spaghetti according to package directions, but stop at “al dente” (about 9–11 minutes). Drain and set aside.

That slightly firm bite is crucial—it holds up well when tossed in a thick, cheesy sauce.

Don’t miss our twist on fusion pasta in Spaghetti Garlic Bread Bowls for another family favorite.

Sear the Chicken to Juicy Perfection

Heat a large skillet over medium-high heat. Add the seasoned chicken and cook for 6–8 minutes, turning occasionally, until browned and fully cooked through. The edges should be a little crisp, locking in that spice.

Once cooked, remove the chicken from the pan and set aside.

Tip: Don’t overcrowd the pan. Cook in batches if needed to avoid steaming the chicken.

Build the Garlic Butter Roux

In the same skillet, melt 4 tablespoons of butter. Add 4 cloves of minced garlic and sauté for 1 minute—just until fragrant, not browned.

Now whisk in 1/4 cup of all-purpose flour to create a roux. Stir constantly for 1 minute to cook off the raw flour taste. This step sets the stage for a thick and flavorful sauce.

Whisk in the Liquids for a Creamy Base

Gradually add 3 cups whole milk and 1 cup chicken broth, whisking as you pour to prevent lumps. Bring the sauce to a gentle simmer over medium heat and let it cook for 3–4 minutes until slightly thickened.

You’ll see the transformation—thin turns rich, and the base starts to coat the back of your spoon.

Want to boost the flavor? Sub half the broth with white wine for a restaurant-level twist.

Stir in the Cheeses for Ultimate Creaminess

Lower the heat and stir in 8 ounces of softened cream cheese until melted and smooth. Then slowly add:

• 1½ cups shredded mozzarella
• 1/2 cup grated Parmesan cheese

Stir until everything is melty, gooey, and incredibly creamy. The result? A sauce that wraps every strand of spaghetti in cheesy garlic heaven.

Add red pepper flakes here if you like extra heat!

Toss Pasta and Chicken into the Sauce

Add the drained spaghetti and cooked chicken back into the skillet. Toss thoroughly, making sure every noodle is coated in the creamy Cajun garlic mozzarella sauce. Let it simmer together for a minute so the flavors marry beautifully.

This is where it all comes together—the boldness of the chicken, the creaminess of the cheese, and the backbone of the pasta.

Broil for a Bubbly Finish

Transfer everything into an oven-safe dish or deep skillet. Sprinkle the remaining ½ cup of mozzarella cheese on top and place under the broiler for 2–3 minutes, or until golden and bubbling.

This final step adds a cheesy crust that seals in all the goodness beneath.

Watch closely! Broilers work fast and can burn quickly.

Serve immediately, and don’t forget a sprinkle of chopped parsley or crushed red pepper for garnish if you’re feeling fancy.

Looking for more cozy comfort food? Discover great ideas like Chicken Tenders in Cajun Lemon Butter Sauce.

Customizations, Variations & Smart Prep for Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Make It Your Own: Substitutions That Still Shine

The beauty of Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce lies in its flexibility. Whether you’re out of ingredients or cooking for dietary needs, here’s how to adapt without losing the magic.

Swap the Spaghetti:
Although spaghetti is classic, you can substitute with:

• Fettuccine for a thicker bite
• Penne for a chunkier, baked-style finish
• Gluten-free pasta to make this Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce celiac-friendly

Chicken Options:

• Don’t have boneless chicken breasts? Use chicken thighs for extra juiciness.
• Try shredded rotisserie chicken to save time—just toss it with Cajun seasoning and warm it before combining with sauce.

Cheese Swaps:

• No mozzarella? Use Monterey Jack or a cheddar blend.
• Want stronger flavor? Smoked gouda adds an exciting twist to your Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce.

Adjust the Heat Without Losing Flavor

We all have different spice thresholds. The Cajun seasoning in Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce already brings heat, but you can easily tune it:

For less heat:

• Use a mild Cajun blend
• Skip the red pepper flakes
• Add more cream cheese or milk to mellow the spice

For more heat:

• Add cayenne pepper
• Double up on smoked paprika
• Stir in hot sauce during the sauce phase

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce should excite your palate—not overpower it.

Meal Prep Tips: Cook Once, Enjoy Twice

This dish is a weeknight hero and a meal prep favorite. Here’s how to make Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce work for future you:

Fridge Storage:

• Store in an airtight container for up to 4 days
• Add a splash of milk or broth when reheating to restore creaminess

Freezer Option:

• Cool completely, then portion into containers
• Freeze for up to 2 months
• Thaw overnight in the fridge and reheat in a skillet with a touch of butter

Batch Cooking:

• Double the recipe and freeze half before broiling
• When ready to eat, top with cheese and broil for fresh-out-the-oven vibes

Discover great ideas like Garlic Parmesan Chicken Meatloaves if you’re craving more freezer-friendly meals that deliver full flavor.

Vegetarian Version of Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Yes, it’s possible—and still delicious!

• Replace chicken with roasted mushrooms, chickpeas, or tofu
• Use vegetable broth instead of chicken broth
• Increase the mozzarella or add vegan cheese alternatives for richness

You’ll still get that signature creamy garlic sauce, just with a plant-based twist.

How to Serve Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce Like a Pro

Make It Look as Good as It Tastes

When it comes to Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce, presentation goes a long way. You’ve spent time layering bold spices and creating a dreamy, creamy garlic mozzarella sauce—now it’s time to plate it like a showstopper.

Best Serving Dishes:

• Use a deep white pasta bowl to let the colors pop—especially the golden Cajun seasoning and bubbly cheese.
• For family-style presentation, serve directly from a cast iron skillet or ceramic baking dish. It keeps the dish warm and rustic.

Garnish for Impact:

• For color and freshness, add some finely chopped scallions or parsley.
• Add a light dusting of paprika or a few red pepper flakes on top for visual appeal and flavor
• For an extra layer, drizzle a little garlic-infused olive oil just before serving

These simple touches elevate Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce from comforting to unforgettable.

Pairing Ideas to Complete the Meal

As rich and satisfying as this creamy Cajun pasta is, the right sides can make your table feel complete.

Crispy or Light Sides That Pair Well:

• Toasted garlic bread or cheesy focaccia
• A crisp arugula salad with lemon vinaigrette
• Roasted green beans or grilled asparagus
• A simple cucumber-tomato salad to cool down the Cajun spice

Bonus: Want to impress guests? Serve this dish alongside white wine—Sauvignon Blanc or Chardonnay pair well with spicy, creamy sauces.

Nutrition Profile of Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Here’s what you’re really getting per serving (approximate values based on 6 servings):

Nutrient	Per Serving
Calories	~640 kcal
Protein	38g
Carbohydrates	48g
Fats	32g
Saturated Fat	14g
Sodium	~880mg
Calcium	High (from cheese and milk)
Vitamin A & C	Moderate (from garlic and paprika)

Health Tip: To lighten it up, reduce the mozzarella by 1/2 cup and use low-fat milk or light cream cheese. You’ll still get a rich texture with fewer calories.

Leftovers That Taste Even Better

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce tastes fantastic the next day—and sometimes even better after the spices settle in. Here’s how to make the most of leftovers:

• Reheat gently in a skillet with a splash of chicken broth or milk to restore creaminess.
• Avoid microwaving without stirring—heat it slowly and evenly for best texture.
• For a fun twist, repurpose into a Cajun pasta bake by adding more cheese on top and baking until bubbly.

Want another rich dinner that reheats like a dream? Don’t miss our Creamy Garlic Seafood Pasta for another indulgent yet easy meal.

Crowd-Sized Tip

Hosting guests? Use a big casserole dish and double the recipe. You can assemble it ahead of time, refrigerate, and just broil before serving. It’s perfect for potlucks, birthdays, or just impressing the in-laws.

The result? A gorgeous golden top, layers of melty garlic mozzarella sauce, perfectly seasoned Cajun chicken, and pasta that feels like a warm hug.

Frequently Asked Questions About Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Conclusion: Why Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce Deserves a Spot in Your Weekly Rotation

If there’s one dish that delivers on comfort, spice, and creamy satisfaction all in a single skillet, it’s undeniably Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce. From the moment you sear that juicy, Cajun-seasoned chicken to the last golden, bubbling layer of mozzarella under the broiler, every step builds a flavor experience that’s both bold and deeply satisfying. This isn’t just a pasta dish—it’s a weeknight dinner savior and weekend indulgence all in one.

You now have everything in your cooking arsenal—from a full breakdown of flavorful ingredients to easy prep tips, swap ideas, and the best way to serve this saucy creation. Whether you’re meal-prepping for a busy week or cooking to impress guests, Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce will never disappoint.

Looking for even more rich, Southern-inspired pasta meals?
Discover this Creamy Garlic Chicken with Roasted Baby Potatoes recipe that pairs beautifully with buttery sides.